The development of horizontal well can promote the effective utilization of low-abundance reservoirs. After years of development, horizontal wells have entered the development stage of medium and high water-cut. Due to the particularity of horizontal well type, interlayer interference occurs, and there is longitudinal reserve loss, which affects the degree of reserve utilization in horizontal wells. Therefore, it is necessary to carry out research on countermeasures to improve the utilization degree of horizontal wells, analyze the situation of segmented utilization of horizontal wells, determine countermeasures to improve the utilization degree of horizontal wells reserves, and provide guidance for the development of similar horizontal wells. By establishing a typical model, different production schemes of horizontal Wells with strong heterogeneity are simulated. Through the comparison of multiple schemes, it is determined that when the permeability difference is 2–10, the staged production effect is better, and the optimal order is to first use the poor physical property layer, and the accumulative oil production is higher when the water content of the difference layer reaches 60%, and then open the horizontal section with good physical property, and the overall development effect of horizontal Wells is the best. When the permeability stage difference is greater than 10, the effect of horizontal well operation becomes smaller and worse. Based on the research basis, the measures to tap the potential, the injection and production relationship adjustment and water injection adjustment in the production process in time to effectively improve the uneven situation of subsection utilization.