The geological conditions of the complex fault-block oil reservoir in the Jidong Oilfield in the Nanpu Sag in the northern Huanghua Depression of the Bohai Bay Basin are complex, with many faults, small fault blocks, and inconsistent oil–water interfaces, resulting in complex water-displacement laws under the dual effects of water injection development in the reservoir. In order to accurately tap the potential of remaining oil and achieve efficient development of oil reservoirs, the “structure-reservoir-model-remaining oil” prediction integrated remaining oil accurate prediction technology is used to reconstruct the understanding system of underground structural reservoirs. Comprehensively utilize numerical simulation technology and mine field experiments to conduct an overall study on the deployment and regulation of differentiated well patterns by zoning and classification, and clarify the principles, objects, reconstruction methods and technical policy boundaries of horizontal zoning and vertical segmentation. The formation of complex fault block layered reservoirs under the dual driving effect of zoning and classification differentiated well pattern adjustment and deployment technology. Through the differentiated design of different driving areas and the differential deployment and regulation of vertical segmentation of plane partitions, the three major contradictions can be effectively improved. It achieves balanced displacement of highly heterogeneous multi-layer sandstone reservoirs in complex fault blocks, effectively improves the water flooding development effect of the block, and provides reference for the rational development of other complex fault block reservoirs in the Jidong Oilfield in the Nanpu Sag.