Natural water bodies are developed in bottom water reservoirs. Natural and artificial water bodies interact with each other in the process of water injection development, and the seepage characteristics are complex. After entering the middle and high water cut stage, the dominant seepage channel is gradually fixed, and the remaining oil is difficult to be produced under the primary well pattern. In view of the above problems, numerical simulation and reservoir engineering methods are combined to study the seepage law of bottom water reservoir in water injection development, and the distribution characteristics of remaining oil under primary well pattern are clarified. Combined with the understanding of geological and development characteristics, it is proposed to optimize the well location deployment of infill adjustment wells, accurate reservoir perforation and transformation, and injection-production policies after fine infill to synergistically tap the potential of remaining oil, and to create an integrated infill adjustment and tapping potential remaining oil technology for bottom water reservoirs in water injection development. The application in the X14 area of the Ordos Basin shows that the water cut of the newly drilled infill oil production well is 20% to 50% lower than that of the surrounding old wells, and the single well production capacity is 1.8–3.4 times that of the surrounding old wells. The production of the old wells is not disturbed, and the predicted recovery rate in the experimental area can be increased by 5% to 8%, indicating that this technology has good potential and application prospects.