Nowadays, artificial intelligence technology has been widely used, and the way of information dissemination has also undergone revolutionary changes. Personal information is also spreading rapidly under the background of big data, cloud computing and other technologies, which makes privacy protection face new challenges. Based on the above background, this paper puts forward an interpersonal communication analysis model of privacy protection system in the era of artificial intelligence, aiming to understand and improve privacy protection system more deeply. In this model, the source and destination of information dissemination can be accurately and clearly distinguished by constructing interpersonal network; Analyzing the speed of information dissemination can help to determine the speed of information dissemination and provide clues for people to take corresponding measures in an emergency; Analyzing the specific path of information dissemination can enable people to grasp how information is disseminated in the network and the possible risks in the process of dissemination; By considering the factor of privacy sensitivity, different levels of privacy protection can be adopted for different information. By integrating the above elements into the analysis model, a more intelligent and personalized method is provided for the privacy protection system, so as to meet the challenges of privacy protection in the era of artificial intelligence, protect the privacy of users and avoid privacy leakage.