Corornavirus disease 2019 is known to be caused by the SARS-CoV-2 virus, which causes severe acute respirational syndrome. A key component of controlling the outbreak has been the use of using vaccinations to combat SARS-CoV-2 infection. Nevertheless, these vaccines come with certain health risks and adverse reactions. Additionally, the emergence of new variants has caused a progressive decay in vaccine effectiveness. Phytomedicines are consistently a worthy therapeutic alternative against viral infections, including coronaviruses. A diverse range of active phytochemicals, along with specific essential oils from frequently employed culinary herbs, spices, and herbal teas, have demonstrated substantial antiviral activity (by either blocking the entry mechanism or inhibiting the viral replication and shedding) while also boosting the immune system. In other respects, plant molecular pharming is a very promising concept of vaccination notably for SARS-CoV-2, it has the features to activate the human immunological responses similarly to the original virus and may be an efficient vaccine.