Shale gas exploration and development in China’s Sichuan Basin, and its surrounding regions, have experienced significant growth in recent years. Particularly noteworthy is the primary production layer, which currently lies within the Wufeng & Longmaxi Formation. Despite abundant shale resources, the exploration and development of deep shale gas in the Sichuan Basin is challenged by un-even distribution of high-quality reservoir, complex lithology, strong structure deformation, and developed fault systems. The favorable longitudinal thickness, less than 5 m, presents further challenges, leading to low natural productivity from single well vertical wells for shale gas–altogether making the geological engineering conditions of shale gas exploration and development significantly complicate. The efficient exploration and development of deep shale gas face numerous challenges such as evaluating high-quality reservoir’s spatial distribution accurately and implementing the target strata precisely, predicting geological sweet spots comprehensively, and designing high-precision horizontal well trajectories scientifically. Real-time monitoring and scientific fracturing represent additional challenges, all of which require the integration of seismic and geological engineering disciplines to improve the productivity of single wells. These challenges demand comprehensive consideration of relatively independent and mutually dispersed multidisciplinary factors such as logging, geology, drilling, and completion, integrating the research, design, and implementation using geo-physical achievements to engineering services. Ultimately, this approach supports the construction of the first domestic shale gas field with “one trillion reserves and ten billion output” in Weiyuan and Changning area, of South Sichuan. In addition, it acquires acceleration for the construction of the second shale gas field with ten billion cubic meters.