The mangrove ecosystem is an area for the discovery of new antiviral compounds due to its exceptional microbial diversity. This study explores the potential of the mangrove microbiome as a valuable source of nature-based products with antiviral properties. Extensive research has revealed a wide array of bioactive compounds derived from mangrove microorganisms, which have demonstrated significant antiviral activities. These compounds have shown efficacy against various viruses, including influenza, herpes simplex, HIV, and more. The current study emphasizes the importance of exploring the untapped potential of rare microbiomes in mangroves for the development of new antiviral drugs. By studying the diverse microbial communities thriving in mangrove environments, researchers can uncover a wealth of natural compounds that hold promise in combating viral infections.