Bioelectronics apparatus is showing tremendous improvement. The design and evolution of biosensor systems have received a focus point for scientists in recent years through the agency of the wide range of sensor implementations, such as environmental monitoring, healthcare and disease diagnostic, food and water quality monitoring, and drug delivery systems. The forthcoming biosensor is encouraging and brilliant and nevertheless needs a steady, cost-efficient and plural disciplinary approach to fetch out biosensors from pilot studies and refinement laboratory to commercial place. In this chapter, renewed emerging technologies and innovative biosensing designs, such as the miniaturisation of sensors, the development of more compact sensors, point of care, smartphone applications, wearable electrochemical biosensors and lab-on-a-chip technology, have been discussed. Eventually, the chapter also takes into account the challenges and future of emerging biosensing technologies in the current times.