The continuous evolution of voltammetric sensors, particularly those incorporating nanomaterials, has revolutionized the field of biosensing, offering unprecedented sensitivity, selectivity, and versatility. This chapter furnishes a comprehensive overview of recent advancements in the fabrication of nanomaterial-based voltammetric sensors. We discuss the unique physicochemical properties of several nanomaterials, comprising carbon-based nanomaterials, metal nanoparticles, and metal oxide nanostructures, that nominate them as ideal candidates for fortifying the performance of voltammetric sensors. The integration of these nanomaterials into sensor platforms is explored, highlighting the latest fabrication techniques, such as electrochemical deposition, self-assembly, and surface functionalization. Special emphasis is placed on the design and optimization of sensor architectures that enable rapid, accurate, and reproducible detection of biological analytes. Furthermore, we examine the practical applications of these sensors in medicinal diagnostics, environmental monitoring, and food safety. Finally, the chapter addresses the challenges and future prospects in the evolution of next-generation nanomaterial-based voltammetric sensors, aiming to inspire further innovation in this dynamic area of research.