A primary objective of sensor research continues to be the creation of sensors characterized by improved stability, specificity, and the capability to function effectively within complex matrices, such as those found in biological and clinical samples. Research activities concerning electrochemical sensors have expanded considerably, owing to the promising qualities these devices exhibit, such as the ability to conduct in situ analyses, provide real-time information, and maintain a low environmental impact. The increasing command for portable, wearable, or implantable sensing devices has aroused the attention of innovative electrode materials and wearable platforms. Wearable sensors are engineered to facilitate healthcare monitoring by seamlessly integrating into our everyday activities. The inclusion of chemical sensors within wearable technologies, such as gloves, tattoos, microfluidics, microneedles, and sweatbands, enables the transition of advanced electrochemical sensors from laboratory settings to practical on-body applications. This chapter aims to reflect some of the latest findings in continuous drug monitoring (COD) in diverse biofluids using novel and advanced voltammetric sensors integrated in wearable platforms in addition to outlining current challenges and future aspects in this field. It throws some light on the wearable sensors that have been successfully used to continuously monitor some target analytes in real time (as physiological biomarkers) like levodopa, caffeine, alcohol, fentanyl and its metabolite, morphine, acetaminophen, glucose, and other biomolecules in various biological fluids including saliva, sweat, and interstitial fluid (ISF). It gave also attention to the approaches engaged in such constructing wearable sensors, their calibration performance, validity, stability, applicability in diverse biofluids for different analytes, and measurement quality using voltammetric sensors. The ongoing advancements in such sensing technology are expected to usher in a new era of modern healthcare. It will autonomously regulate drug dosing based on the patient’s health responses, facilitating disease management and improving personalized therapy.