Climate change poses a significant threat to global food security, particularly for crop resilience. This chapter explores the complex and far-reaching influences of climate change on a wide range of crops, including vegetables, cereals and pulses. To address these challenges, a comprehensive and multidisciplinary approach is essential, and it offers a promising approach. Genomics, transcriptomics, metabolomics, proteomics, phenomics and ionomics provide a comprehensive understanding of the genetic, molecular and physiological mechanisms underlying crop responses to climate stress. By integrating these approaches, scientists can find key genes, pathways and metabolites involved in stress tolerance. This knowledge can be leveraged to develop climate-resilient crop varieties through breeding, genetic engineering and agronomic management practices. The chapter highlights the potential of multi-omics strategies in enhancing crop resilience by improving stress tolerance, yield stability and nutritional quality. Future research efforts should aim to expand the application of multi-omics techniques to a wider range of crop species and diverse climatic conditions. By integrating multi-omics data with field phenotyping and modelling, researchers can gain a more holistic understanding of how crops respond to climate change, ultimately facilitating the development of robust adaptation strategies.