In this study, we have designed Unmanned Aerial Vehicles (UAV) featuring twin booms and an inverted V-tail configuration. By employing the Multiple Reference Frame (MRF) method, we have conducted comprehensive computations to analyze the aerodynamic performance of the twin-boom UAVs with various propeller installation positions. Our findings indicate that the propeller's slipstream produces a significant influence on the pressure distribution across the wing surface, effectively weakening flow separation at the wing's trailing edge. Additionally, the in-verted V-tail design induces a negative downward lift in the forward section of the tail, which subsequently diminishes the lift enhancement contributed by the propeller slipstream. Insights into the impact of propellers slipstreams in various locations are presented, laying a foundation for further exploration on twin-boom configuration UAV design.