Bio-inspired leading-edge tubercles were adopted to the subsonic high-camber diffusion cascade. Numerical simulations were conducted at a Mach number of 0.2 to investigate the impact of two key design parameters: wavelength and amplification factor, on the flow field. The study encompassed multiple incidence angles ranging from –16° to +16°. Results indicate that cascade with leading-edge tubercles significantly reduce total pressure loss and effectively control flow separation in the post-stall region, while having almost no adverse effects in flow field at design incidence angle. For cascade with tubercles characterized by a wavelength of 11.25 mm and an amplification factor of 1.005, the total pressure loss coefficient decreased by approximately 7.3% compared to cascade without tubercles at a + 12° incidence angle.