Sustainable Architecture has become increasingly relevant in the context of global warming. The rising population contributes to higher energy consumption and demand, which in turn leads to increased greenhouse gas emissions and climate change. A significant method for reducing energy use in buildings is through creating thermal comfort passively via Natural Ventilation; particularly in Hot-Humid regions. This paper seeks to identify an effective building block orientation and arrangement within a residential complex in Chennai, utilising three key site parameters: dimensions, orientation, and spacing between blocks; employing Computational Fluid Dynamics (CFD) simulations to evaluate how these factors influence indoor wind comfort indices. Final findings indicate that Staggered block arrangement with an orientation angled between + 30° and + 45° towards the South-East is optimal for capturing the annual winds (South-West), achieving ideal wind velocities. Furthermore, the linear interior layout performs superior compared to other proposed designs. Also, the study emphasises the analysis of interior layouts in relation to the identified optimal block configuration, serving as a foundational guide for designing building block arrangements that promote sustainable housing through wind-driven Natural Ventilation.