With the potential to improve performance and safety, nanofillers have become popular additions to food packaging. This chapter gives an overview of the function of nanofillers in food packaging, including how they affect barrier features, mechanical strength, and food quality preservation. The advantages of several types of nanofillers for use in food packaging materials, such as clay nanoparticles, metal oxide nanoparticles, and carbon-based nanoparticles, are highlighted. The choice and compatibility of nanofillers with ingredients in food and components of the packaging are also investigated, emphasizing the significance of surface modification methods and optimizing nanofiller loading and dispersion. This chapter also looks at the several ways that nanofillers are used in food packaging, including active packaging, intelligent packaging, and barrier coatings. The necessity for risk assessment and safety evaluation, as well as safety and regulatory issues related to the use of nanofillers in food packaging, is discussed. The field’s obstacles and future prospects are examined, with a focus on the packaging materials made using nanofillers’ role in rising trends and environmental sustainability. Overall, this chapter highlights the crucial part that nanofillers have played in reshaping food packaging and the need for more research and development in this field. Food packaging may be improved to assure greater product quality, longer shelf life, and increased customer safety by utilizing the special qualities of nanofillers.