Under today’s natural environmental, social and technological conditions, the global and large-scale challenges faced by humanity are becoming increasingly significant, making collaborative work increasingly important. Computer-Supported Cooperative Work (CSCW) is anticipated to assume a more pivotal role in modern society and within the fabric of production and daily life. In recent years, Artificial Intelligence has witnessed remarkable advancements, and the “cooperative intelligence” of AI systems has been enhanced. The role of computers in supporting human collaboration is no longer limited to an auxiliary role but also serves as a cooperative role, bringing new challenges to the study of CSCW, ranging from basic collaborative theories to key technologies. This paper proposes a new frontier in CSCW, AI Supported Cooperative Work (AISCW) and its system research. The objective is to take use of AI technologies to enhance and optimize human collaborative activities. By delving into the interplay between CSCW and AI, this paper outlines the foundational concepts, key issues and potential research focal points of AISCW.