Deep shale is characterized by strong anisotropy, which result in significant differences in the vertical and horizontal acoustic time differences, directly affecting the interpretation accuracy of key reservoir parameters. This paper combines shale acoustic rock physics experiments and numerical simulation methods to study the factors affecting the macroscopic and microscopic anisotropy of deep shale acoustic waves. It analyzes the acoustic response characteristics under different clay content, organic matter content, and well inclination angles, and establishes a correction chart for deep shale acoustic wave anisotropy. Research has shown that the microscopic anisotropy coefficients of longitudinal and transverse waves increase with the increase of clay content, but displayed a poor relationship with organic carbon content. The macroscopic anisotropy coefficients increase with the increase of well inclination angle. As the well inclination angle and anisotropy parameter increase, the difference between acoustic waves in the vertical and horizontal directions increases. When the anisotropy parameter is greater than 0.1 and the well inclination angle is greater than 30°, the difference between the two is significantly enhanced. Under the same elastic anisotropy formation, the correction amount for longitudinal wave travel time in horizontal wells is greater than that for transverse wave travel time. The relative value of the difference in acoustic time between horizontal and vertical wells is polynomial related to the sine square of the well inclination angle. The established macroscopic and microscopic longitudinal and transverse wave anisotropy correction models provide reliable data for fine processing and interpretation of horizontal well logging data.