In fact, several small industrial scale uses of CO2 together can create a great impact on making of the environment, economy and life sustainable on earth. In this chapter, various industrial applications of CO2, and various potential chemicals being synthesized from CO2, and its direct uses in various applications are presented. So far, CO2 was employed as a feedstock for the synthesis of industrial chemicals such as, (i) methanol from syngas by following thermochemical routes, (ii) salicylic acid by heating a mixture of sodium phenoxide and CO2 under pressure at 180–200 °C, (iii) urea and plastics synthesis in spontaneous, stoichiometric, neutralization (i.e., acid–base), thermodynamically downhill reactions, etc.. Except plastics synthesis from CO2, remaining all other major chemical synthesis routes have been described in this chapter. The current industrial status of (i) algae (sea-weed) production, (ii) reverse microbial fuel cells (R-MFC) on electrochemical CO2 reduction to various fuel chemicals, etc., has also been described.