This paper conducts an in-depth analysis of the primary utilizations of interoperability capabilities within the sphere of system-of-systems combat operations, elucidating the transformative impact of such technology on bolstering the operational effectiveness of contemporary military systems. The paper meticulously scrutinizes the historical progression of strategic deployments of advanced intelligent military technologies throughout various stages of development within the United States’ defense apparatus. Its effort extracts and synthesizes the fundamental technological strategies that have been instrumental in facilitating a continuous and incremental improvement in the interoperability of U.S. military combat systems. The research, drawing from this critical review, delineates essential breakthroughs that are imperative for the future research and development endeavors in the realm of interoperability technology. These findings are meticulously aligned with the pressing requirements of maintaining a competitive edge in an information-centric modern warfare scenario. The insights proffered by this study are instrumental in shaping the trajectory of military technological advancement, ensuring a robust and cohesive operational interoperability framework capable of meeting the complex challenges of contemporary conflicts.