With the increasing technical complexity of aerospace, aviation, vehicles, ships and other equipment. The traditional concept of “health” evaluation in social, ecological and economic fields has been gradually popularized and applied in aerospace and other complex equipment fields. In the health evaluation of complex objects, it is obviously not comprehensive to evaluate things only according to a single feature. Health evaluation needs to comprehensively evaluate the different characteristics of the object. Therefore, the health evaluation of complex objects can be regarded as a kind of multi-index comprehensive evaluation problem. The corresponding evaluation method is called multi-index comprehensive evaluation method. The problem of multi-index comprehensive evaluation involves different evaluation indexes of the evaluation object. The core idea of multi-index comprehensive evaluation is to determine the weight of each evaluation index according to the influence of the evaluation index on the final evaluation goal. In this paper, thirteen comprehensive health evaluation indicators in a large constellation were selected. The information entropy theory is introduced to determine the index weight, establish the spacecraft health comprehensive evaluation model. The comprehensive health index method was used to evaluate the health status of a series of spacecraft.