A midcourse differential game penetration guidance law for ballistic missiles considering handover point is presented in this paper. This novel guidance law incorporates returning to the handover point in its design. Viewing the handover point as an enemy member, the penetration task is segmented into two phases: the penetration phase and the homing phase. The performance indexes are designed based on the unique characteristics of tasks in various phases, especially introducing the terminal distance between the ballistic missile and the handover point. Subsequently, an analytical solution for the proposed differential game guidance law is derived. The simulation results illustrate the effectiveness of the proposed guidance law.