The detection of explosives is a critical area of research, and metal-organic frameworks (MOFs) have emerged as a promising class of materials for this application. These materials offer unique advantages such as high surface area, adjustable pore size, and selective molecule adsorption, which make them highly desirable for sensing applications. This in-depth review article summarizes recent advancements in the design and synthesis of MOFs for explosive detection. The sensing mechanisms and performance of MOFs highlight their high sensitivity, selectivity, and reproducibility. This chapter explores the potential real-world applications of MOFs as explosive sensors, including their use in public safety, environmental monitoring, and military operations. However, the use of MOFs as explosive sensors also presents challenges such as stability, selectivity, and reproducibility under varying environmental conditions. This provides insights into the latest research efforts to address these challenges, including the use of functionalized MOFs, novel sensing platforms, and advanced characterization techniques. Furthermore, this chapter directs in this rapidly evolving field, with a focus on the development of MOFs with improved sensing performance and real-world applicability.