Metal-organic frameworks (MOFs) have emerged as a promising class of materials for the detection of hazardous chemicals due to their high porosity, large surface area, and tuneable chemical and physical properties. The unique structural features of MOFs make them ideal for the detection of a wide range of hazardous chemicals, including toxic gases, heavy metal ions, explosive compounds, Volatile Organic Compounds (VOCs), radioactive materials, and environmental pollutants. MOF-based sensors have shown excellent sensitivity and selectivity towards hazardous chemicals, which makes them highly desirable for a variety of applications, including industrial safety, environmental monitoring, and homeland security. MOF-based sensors can be designed to operate under a wide range of environmental conditions and can be easily integrated with existing sensor networks, which makes them highly scalable and cost-effective. Recent advancements in the synthesis and characterization of MOFs have led to the development of a wide range of MOF-based sensors with improved performance characteristics, such as enhanced sensitivity, selectivity, and stability. The design and optimization of MOF-based sensors for the detection of hazardous chemicals is an active area of research, and ongoing efforts are focused on improving the performance and versatility of these sensors.