This book chapter discusses the novel use of Metal-Organic Frameworks (MOFs) in fingerprint identification, combining materials science, chemistry, and forensics. MOFs’ high porosity, adjustable architectures, and various functions make them a suitable platform for fingerprint detecting technology. First, the chapter covers fingerprint analysis basics, highlighting the necessity for sensitive and selective methods in forensic investigations. It then discusses MOFs’ customizable nature and large surface area, making them excellent for fingerprint detection. The chapter concentrates on fingerprint-analysis MOF synthesis and design. This involves discussing MOF architectures with functional groups that selectively interact with latent fingerprint components. The chapter also discusses using MOFs as adsorbents to remove molecules from fingerprint residues to improve latent print visibility and persistence. The book chapter also discusses MOF incorporation into fingerprint detecting problems and potential. Scalability, repeatability, and real-world application of MOF-based forensic procedures are considered. This book chapter combines materials science and forensic technology to help researchers, forensic scientists, and professionals improve fingerprint detection techniques. MOFs may improve fingerprint analysis sensitivity and reliability, opening new options for forensic investigations and advancing twenty-first century forensic research.