Openings in beams can be used to accommodate mechanical, electrical, and plumbing services. Using openings in reinforced concrete beams saves the need for the area under the floor plate and above the ceiling and reduces overall building height. However, these openings change beam behavior, reducing stiffness and capacity and increasing deflection and crack expansion. In this study, six reinforced concrete beams with non-symmetrical multiple 4-inch or 100 mm diameter openings spaced 200 mm apart were tested monotonically under two-point loads. Three specimens were used as controls without CFRP sheets, and three were strengthened with CFRP sheets with three different longitudinal tensile reinforcement values. CFRP sheets were installed on both sides in the area around the openings. The shear force–deflection and crack patterns indicated that gluing CFRP sheets in the area around the opening can increase the shear capacity by about 18–40% and result in flexural failure. In contrast, beams without CFRP sheets experienced shear failure.