Cardiovascular disease (CVD) continues to be a predominant cause of global mortality and morbidity, presenting an urgent need for advanced therapeutic and diagnostic strategies. Nanotechnology has emerged as a groundbreaking field with the potential to revolutionize CVD management through its unique capabilities in targeted drug delivery, improved diagnostic techniques, and novel therapeutic interventions. This book chapter delves into the current advancements and applications of nanotechnology in CVD management, highlighting the use of nanoparticles, liposomes, dendrimers, and nanosensors. These nanocarriers offer significant benefits, including enhanced drug bioavailability, reduced systemic toxicity, and precise delivery to specific diseased tissues, thereby improving therapeutic efficacy and patient outcomes. Furthermore, the integration of nanosensors in diagnostic processes allows for early and accurate detection of cardiovascular conditions, facilitating timely intervention. The chapter also discusses the challenges and future perspectives in the clinical translation of nanotechnology-based therapies for CVD, aiming to provide a comprehensive understanding of this innovative approach in the fight against cardiovascular diseases.