Psoriasis is a well-known, chronic, immune-mediated inflammatory skin disease affecting almost 2–4% of the world population. Psoriatic skin lesions manifest due to both the attenuation of oxidative stress and adverse immune response, resulting in hyperproliferation and inflammation of the epidermal keratinocyte. Phenolic hydroxyl group-containing organic molecules, Polyphenols, have demonstrated their potential utility as antioxidants and anti-inflammatory agents. However, their application is limited due to their susceptibility to environmental conditions and low bioavailability. Recently, nanoformulations were proposed to overcome such limitations and maximise the pharmacological effects of polyphenols. By focusing on the interactions between polyphenols and different nanoformulations (e.g., Liposomes, Niosomes, Ethosomes, Ufasomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers, and dissolvable microneedles). This chapter sheds some light on the synthesis and properties of the polyphenol-containing nanoparticles. Additionally, the remarkable versatility of polyphenol-containing nanoparticles in various preclinical studies targeting psoriasis management is also demonstrated. Finally, the challenges faced by future research regarding the polyphenol-containing nanoparticles are discussed.