Base isolation has emerged as one of the most widely used techniques of passive vibration control of structures in recent times with the elastomeric-based systems leading the way right at the forefront. Several configurations and designs have been experimented with from time-to-time yielding results mostly for the better than worse. Among the most recent advances in the realm is the use of Unbonded Fibre Reinforced Elastomeric Isolators (U-FREIs) which has proved to be promising for the reduction of the cost and complexity of implementation, especially for application in small-scale constructions in developing nations. However, the inherent problems of transfer of tensile stresses and the possibility of slip at the interfaces with the structure and the foundation have been identified in the literature and work has been done towards improvement leading to the proposition of Partially Bonded Fibre Reinforced Elastomeric Isolators (PB-FREIs). The present work is an attempt to put the PB-FREIs to application in base isolation of Reinforced Concrete (RC) building structures which has not been found in the literature to assess their performance and effectiveness in response control. Herein, PB-FREIs are theoretically designed for a selected RC structure located in Dharmanagar, a town in the state of Tripura, India (seismic zone V) in line with the guidelines of standard codes, followed by 3D numerical modelling of the same in a Finite Element (FE) software to determine the properties of the vertical stiffness, the horizontal stiffness and the equivalent viscous damping which are then used to isolate the structure in a structural analysis software and perform analysis to check the response control achieved. Significant increase in time period of the structure has been observed establishing the effectiveness of the isolation system.