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Polyhydroxyalkanoates (PHAs) have emerged as potential solution to combat plastic pollution due to their biodegradability. However, higher costs associated with biosynthesis of PHA is due to expensive substrates, extended growth periods of the microorganisms, and the relatively low yield. It is estimated that the costs involved in PHA production is approximately 3–12 times more than traditional plastics, hindering PHA’s economic feasibility. Advances in recombinant DNA technology offer to reduce production costs as use of various affordable substrates can be explored for genetically engineered organisms for the biosynthesis of PHA. E. coli is a well-studied microorganism with established genetic engineering techniques, making it an excellent prospect for PHA production. This chapter highlights the ongoing efforts to explore E. coli-based PHA production.

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Insights into Polyhydroxyalkanoates Producing Engineered E. coli

  • 章节

  • 发表日期：

    2025年

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  • Gayatri Dhananjay Kulkarni,
  • Poorva Umesh Mahale,
  • Shraddha Rajendra Joshi,
  • Seema Prabhudev Rodge

摘要

Polyhydroxyalkanoates (PHAs) have emerged as potential solution to combat plastic pollution due to their biodegradability. However, higher costs associated with biosynthesis of PHA is due to expensive substrates, extended growth periods of the microorganisms, and the relatively low yield. It is estimated that the costs involved in PHA production is approximately 3–12 times more than traditional plastics, hindering PHA’s economic feasibility. Advances in recombinant DNA technology offer to reduce production costs as use of various affordable substrates can be explored for genetically engineered organisms for the biosynthesis of PHA. E. coli is a well-studied microorganism with established genetic engineering techniques, making it an excellent prospect for PHA production. This chapter highlights the ongoing efforts to explore E. coli-based PHA production.