Aligning to the goals of sustainable development (SDG 12), the food safety and environmental sustainability are heavily compromised by plastic contamination, and the negative effect of traditional plastics on the packing of foods is a matter of concern. Food packaging plays a crucial role in the food industry. The responsible consumption and production of food is safeguarded against harmful microbes and pollutants in the environment using proper packaging. This measure ensures that the food remains untainted and suitable for consumption. Food comes with a specific shelf life, hence requiring proper preservation to avoid spoilage. Recent advances in packaging are observed by using biodegradable natural polymers. Polyhydroxyalkanoates (PHA) as a plastic hold great potential because of its good biocompatibility and biodegradability along with high tolerability if eaten. Active food packaging which includes resistance against bacterial and fungal infections will provide the additional benefit of defense against microbes. This biodegradable polymer PHB packaging ensures food safety and can serve as a reliable food preservation packaging polymer shortly. This review is centered on polyhydroxyalkanoates (PHA) to understand how effective it can be in solving the problems caused by conventional plastic packaging on human health and our ecosystem.