Abundant literature has come upon Workplace Spirituality. Evidence-Recent years have seen an increase of scientific interest in spiritual intervention (SI) for improvement of various mental health constructs. To meet this growing need there is surge in scientific literature where researchers examined the efficacy of SI on mental health. However, there is lack of extensive and systematic review on it. The aim of the present paper is to present a systematic and extensive review of scientific literature. A total of six databases were used and various terms related to SI and mental health was combined to identify relevant published literature. A particular inclusion criteria is used to filter relevant literature. Total of 4000 articles were identified using the criteria, however 27 studies were included for review after filtering the studies for a particular time span. The review presents very interesting yet very useful insights about SIs. Most of the researches overwhelmingly supported the idea that SI does improve mental health and well-being however; the critical question arises before considering spiritual intervention as potential predictors. The definitions of the spirituality and spiritual intervention differed a lot in most of the studies. Most of the intervention varied in delivery timing from three weeks to twelve weeks. In addition to it the content and techniques used in SIs were also different and unique to every study. Therefore to predict SI as a potential predictor for various positive changes in mental health and wellbeing, can be sometimes misleading. Since many aspect of SIs needs to be checked and validated before identifying it as intervention program. The present review discusses not only pros of such intervention studies but also presents various potential threats which can help to make SI as evidenced based intervention program.