After meeting its own power supply and demand balance, the micro energy grid uses the surplus output of each equipment to quickly respond to the dispatch demand of the superior power grid. Aiming at the problem of weak response ability of a single micro energy grid, a method of internal scheduling optimization and response of micro energy grid is proposed. Firstly, the basic structure of micro energy grid is established, and the multi-agent cooperative operation mode is proposed. Then, the internal scheduling optimization model of micro energy grid is established, and the flexibility response ability is measured. Finally, in order to improve the enthusiasm of multi-agent participating in cooperative scheduling and internal units participating in operation optimization, the optimization model of micro energy grid responding to higher power grid is proposed. The results of the example show that the internal dispatching cost and the total operation cost of the upper power grid of the micro energy grid are significantly reduced, which proves the effectiveness of the method.