The evidence-based literature included in this chapter provides an in-depth understanding of various aspects related to clinical social work practice and education. The content in the chapter includes but is not limited to topics such as a historical overview of the development of clinical social work, the skills required for clinical social work in the twenty-first century, harm reduction guidelines for clinical social work practitioners, the state of clinical social work in South Africa, COVID-19 and clinical social work and social work education and clinical learning.