This study introduces the development and application of a set of novel lightweight wireless self-powered (LWSP) infrastructure monitoring sensors, which have the functions of large-scale, low-power wireless data transmission, environmental energy self-collection, intelligent sensing of infrastructure, etc., and have the ability to operate in various complex environments for a long time. The power supply system can meet the long-term monitoring needs of infrastructure service performance and greatly improve the coverage and effectiveness of infrastructure service performance monitoring. In this work, power collecting by the energy harvesting unit is maximized by optimizing the sensor system design. Finally, to confirm the functions and applicability of new LWSP monitoring sensors, the case study of bridge monitoring based on the actual conditions of bridges, and formulate an LWSP monitoring plan following the principle of bridge. The proposed technique will enhance the sustainability and performance of infrastructure monitoring based on novel LWSP sensors compared to the conventional method, showing the excellent monitoring capability of these new sensors.