In the process of oilfield exploitation, barium sulfate scaling seriously affects production efficiency, increases maintenance costs, and has potential safety hazards. It is of great significance to study effective barium sulfate removal technology to ensure stable production and reduce operating costs in oilfields. The purpose of this paper is to explore the background of barium sulfate removal in oilfields and its practical application value. This study focused on the development of high-efficiency BaSO4 descaler, and successfully developed LB descaler by combining DTPA as the main agent and combining oxalic acid and other synergists, which had a significant descaling effect on BaSO4. After experimental verification, the optimal formulation of LB descaler was determined, in which the ratio of DTPA to oxalic acid was 1:1. The descaling rate was as high as 82.00% after 12 h of reaction under the conditions of 5% addition, 80 °C reaction temperature, and pH 5. This result provides a new and effective method in the field of BaSO4 descaling.