The soil-foundation interaction (SFI) plays a vital role in the force response of the RC frame elements, which duly needs to be accounted during modeling to obtain accurate internal force distribution for which the design should be carried out. In this study, a typical G + 3 building symmetric in plan is considered. The modeling and analysis for gravity loading were carried out using STAAD software. The analyses were performed for frames (without plinth beams) with both fixed and flexible base conditions. Three different soil strata, viz., soft clay, loose sand and dense sand, were considered for the flexible base condition. The spring stiffnesses of the isolated footings resting on soil were calculated as per the available expressions in ASCE / SEI 41-17 and incorporated in the models accordingly for accounting SFI. The analysis results are presented for an intermediate frame. The influence of SFI on the force response and design of beams, columns and footings was explained in great detail. On comparing the results, it was found that the forces on the footing decreased significantly in the case of flexible bases. A maximum reduction in the required area of steel reinforcement by 24. 65% and 24.36% of footings of interior and exterior columns, respectively, was noticed in the case of a frame resting on loose sand. A maximum increase in hogging moment and corresponding required area of steel reinforcement by 33.47 % and 44.29 % was observed in the beams. A maximum increase in hogging moment and corresponding required area of steel reinforcement by 33.47 % and 44.29 % was observed in the end span beams. The maximum increase and decrease in the required area of main steel reinforcement in the columns was noted as 195.82% and 37.79%.