Physical therapists who instruct rehabilitation for their patients and staffs in welfare facilities who help residents take bath and do other things both face a common troublesome problem on managing the pain that the care receivers claim or causes violation without any notification. Because many methods depend on the self-report by care receivers that is not reliable in most cases (they tend to exaggerate the anxiety for pain). Past research on pain, on the other hand, have clarified facial expressions were reliable enough than words but at the same time they had large individual difference in the location of pain facial expression. This paper reports a method of predicting where pain facial expression appears only by taking an image of face with neutral expression and analyzing it with respect to permanent wrinkles. Successful prediction of pain facial expression enables for care givers to prevent pain-inducing care from continuing unintendedly.