Titanium and its alloys are extensively used in different biomedical applications, such as cardiovascular and orthopedic implants. Using additive manufacturing, user-specific implants can be easily fabricated. However, the chances for corrosion growth exist owing to the contact between metal and surrounding electrolytic environment, such as bone and muscle. Hence, due to the corrosion, biocompatibility and toxicity issues may exist, which can cause problems, such as aseptic loosening, implant failure, and short life. Therefore, it is necessary to evaluate such biomaterials’ toxicity and corrosion behavior to avoid the damage that may occur within the human body. Hence, in this study, a simulation of the corrosion behavior of Ti6Al4V has been performed using Multiphysics simulation-based platform known as COMSOL. A 2D model and 3D bone in a screw model have been developed and simulated. Electric current density and change in overall thickness with respect to time were computed. The current density of 1.51 × 10–7 A/cm2 was obtained with a total reduction of 4.06 µm in 365 days. The corrosion rate was also evaluated and was found to be 1.327 × 10–4 mmpy. Furthermore, a comparison of corrosion behavior between the simulated data and experimental data of Ti6Al4V from previous studies has been carried out. The simulation results were found to be within the permissible range of previously reported experimental studies with a maximum deviation of 3.56%.