A two-degree-of-freedom vibration isolation platform with large horizontal vibration amplitude is proposed, which can be used for high-end precision equipment. The traditional vibration isolators have the inherent contradiction of high static support capacity and low initial vibration isolation frequency, which is difficult to solve the problem of low frequency vibration isolation. In order to improve the performance of low frequency vibration isolation, a novel 2-3UU/US hybrid mechanism with high static and low dynamic stiff-ness is designed. First, the working principle and quasi-zero stiffness space of 2-3UU/US are analyzed, and the quasi-zero stiffness characteristics of the designed platform at static equilibrium are verified. The dynamic model of the designed platform is established, and the amplitude-frequency response characteristics and transmissibility of the isolator are obtained by harmonic balance method. Through the simulation results of Adams model, it is verified that the designed vibration isolation platform has good vibration isolation performance.