Inpatient hospitalization is often used as a method of ensuring safety for patients having acute and high-risk psychiatric emergencies. The primary goals of inpatient treatment include preserving the patient’s life and safety, reducing or eliminating suicidal intent and ideation while treating underlying disorders, and improving the mechanisms available to the patient to permit them to cope after discharge. While there are benefits of inpatient hospitalization, especially keeping the patient safe and alive, the period after discharge can be a vulnerable time in which patients might be susceptible to several factors that increase suicidality. While there is variation on the amount of time in which patients are at the highest risk, there is overwhelming data that cautions against the vulnerability that patients experience during the post-discharge period. This chapter will examine factors that contribute to post-discharge suicidality, examine methods of prevention, and explore methods that may reduce risk during the transition period between hospitalization and discharge. More research is needed in order to implement effective post-discharge support resources for patients and their families and to identify safe alternatives to inpatient hospitalization when warranted, in the hopes that suicide prevention procedures will be evidence-based and prioritize the needs of the patient.