With the development of the concept of cyber-physical systems (CPS), the integration of distributed generation units and energy storage into distribution grids, and the increasing penetration of renewable energy, the level of renewable energy integration and the economic operation of the new power system face higher challenges. Therefore, this paper proposes a multi-objective optimization strategy for distribution grid considering the life span of energy storage and CPS architecture. First, a framework coupling the information system and physical system is established, and the influence of the primary system on the secondary system is analyzed. Then, considering the number of charging and discharging cycles and the depth of discharge, a model of energy storage life span degradation is established, and a multi-objective optimization strategy for economic dispatch of distribution grid considering the life span of energy storage is established. The results show that the optimization strategy considering the life span of energy storage can reduce the amount of battery charging and discharging, reduce maintenance costs, and achieve more efficient economic operation.