Aiming at the problems of node voltage violation and power flow reversal caused by large-scale distributed generation access, this paper proposes a coordinated optimization operation strategy of active and reactive power based on electric-hydrogen system and data-driven power flow analysis. Firstly, a data-driven power flow analysis model is established to describe the nonlinear mapping relationship between operation conditions and power flow results from the perspective of data-driven, which avoids the influence of convergence of numerical calculation method and accuracy of distribution network parameters on power flow calculation and subsequent coordinated optimization of active and reactive power in the distribution network. On this basis, the coordinated optimization of active and reactive power in the distribution network based on electric-hydrogen system and data-driven power flow analysis is established. The coordinated optimization of active and reactive power in the distribution network is realized by using photovoltaic power supply and electric-hydrogen system, and the problems of voltage violation and power flow reversal in the distribution network are solved. Finally, the effectiveness of the proposed strategy is verified by IEEE 33-bus system.