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Cell therapy has been explored for its potential in treating male hypogonadismMale hypogonadism in adults. The disorder is characterized by low testosteroneSex hormonestestosterone levelOutcome indicatorstestosterone level and male sexual dysfunctionsexual dysfunction. Although testosterone replacement therapyTestosterone replacement therapy can help to alleviate symptoms, patients may suffer from side effects, such as an increased risk of cardiovascular disordersSide effectsincreased risk of cardiovascular disorders and prostate cancerSide effectsincreased risk of prostate cancer. Novel approaches in regenerative medicine might pave the way for modern therapies that target on the etiology of the diseases instead of merely managing the symptoms. Preclinical studiesPreclinical studies have highlighted the potency of mesenchymal stem cellsMesenchymal stem cells (MSCs) from adipose tissueMesenchymal stem cellsfrom adipose tissue, bone marrowMesenchymal stem cellsfrom bone marrow, and umbilical cordMesenchymal stem cellsfrom umbilical cord to enhance testosteroneSex hormonestestosterone levelsEfficacyenhanced testosterone levels and reduce damage of testicular tissuesEfficacyreduced damage of testicular tissues. Furthermore, stem Leydig cellsStem Leydig cells derived from the testisTestis and Leydig-like cellsLeydig-like cells differentiated from human induced pluripotent stem cellsInduced pluripotent stem cells (iPSCsiPSCsInduced pluripotent stem cells) have also successfully restored low testosterone productionEfficacyrestored low testosterone production, improved spermatogenesisEfficacyimproved spermatogenesis, and alleviated testosterone deficiencyTestosterone deficiency symptomsEfficacyalleviated testosterone deficiency symptoms. Early-phase clinical trials have indicated that cell therapy is safe and may lead to significant improvements in testosterone levelsTestosterone levels and sexual healthSexual health. This emerging field holds potential to improve patient outcomePatient outcomes but requires much attention to develop effective treatments for testosterone deficiencyTestosterone deficiency and male sexual dysfunctionMale sexual dysfunction.

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Cell Therapy for Testosterone Deficiency and Male Sexual Dysfunction

  • 章节

  • 发表日期：

    2025年

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  • Van T. Hoang,
  • Nguyen Thi Tan Sinh

摘要

Cell therapy has been explored for its potential in treating male hypogonadismMale hypogonadism in adults. The disorder is characterized by low testosteroneSex hormonestestosterone levelOutcome indicatorstestosterone level and male sexual dysfunctionsexual dysfunction. Although testosterone replacement therapyTestosterone replacement therapy can help to alleviate symptoms, patients may suffer from side effects, such as an increased risk of cardiovascular disordersSide effectsincreased risk of cardiovascular disorders and prostate cancerSide effectsincreased risk of prostate cancer. Novel approaches in regenerative medicine might pave the way for modern therapies that target on the etiology of the diseases instead of merely managing the symptoms. Preclinical studiesPreclinical studies have highlighted the potency of mesenchymal stem cellsMesenchymal stem cells (MSCs) from adipose tissueMesenchymal stem cellsfrom adipose tissue, bone marrowMesenchymal stem cellsfrom bone marrow, and umbilical cordMesenchymal stem cellsfrom umbilical cord to enhance testosteroneSex hormonestestosterone levelsEfficacyenhanced testosterone levels and reduce damage of testicular tissuesEfficacyreduced damage of testicular tissues. Furthermore, stem Leydig cellsStem Leydig cells derived from the testisTestis and Leydig-like cellsLeydig-like cells differentiated from human induced pluripotent stem cellsInduced pluripotent stem cells (iPSCsiPSCsInduced pluripotent stem cells) have also successfully restored low testosterone productionEfficacyrestored low testosterone production, improved spermatogenesisEfficacyimproved spermatogenesis, and alleviated testosterone deficiencyTestosterone deficiency symptomsEfficacyalleviated testosterone deficiency symptoms. Early-phase clinical trials have indicated that cell therapy is safe and may lead to significant improvements in testosterone levelsTestosterone levels and sexual healthSexual health. This emerging field holds potential to improve patient outcomePatient outcomes but requires much attention to develop effective treatments for testosterone deficiencyTestosterone deficiency and male sexual dysfunctionMale sexual dysfunction.