Cerebral strokeCerebral stroke is a leading cause of morbidity and mortality worldwide, with limited therapeutic options to effectively restore lost neurological function. Cell therapy has emerged as a groundbreaking approach to enhance neuroregeneration and functional recoveryOutcomesfunctional recovery after strokeCerebral stroke. This chapter provides a comprehensive overview of the preclinical applications of cell therapyCell therapy for cerebral strokeCerebral stroke, using various cell types including neural stem cells mesenchymal stem cellsMesenchymal stem cells and bone marrow-derived mononuclear cellsBone marrow-derived mononuclear cells each with distinct mechanisms of actionMechanisms of action such as neuroprotectionMechanisms of actionneuroprotection and neurogenesisMechanisms of actionneurogenesis, immunomodulationMechanisms of actionimmunomodulation, and angiogenesisMechanisms of actionangiogenesis. The chapter also outlines the indicationsIndications and contraindicationsContraindications for cell therapyCell therapy in strokeCerebral stroke patients, as well as cell sources and doses, delivery route. Additionally, the chapter addresses the associated side effectsSide effects, potential complicationsComplications, and clinical outcomesOutcomes observed in recent trials. By integrating findings from preclinical and clinical studies, this chapter aims to provide a comprehensive overview of the current state of cell therapyCell therapy for cerebral strokeCerebral stroke and to discuss future directions for research and clinical application, emphasizing the need for standardized protocols, rigorous clinical trialsClinical trial, and advanced research to optimize the safetyCell therapysafety and efficacy of cell therapyCell therapy for strokeCerebral stroke patients.