According to application requirements and characteristics of the application object, gas cleaning membranes are often suitable for different configurations (such as flat, tubular, bag, hollow fiber, etc.), and different design requirements are proposed for membrane components and equipment. In addition to possessing good gas tightness and high-low temperature reliability, membrane separation equipment also needs to consider compatibility with membrane materials. Therefore, this Chapter will comprehensively analyze the basic properties of the target separation system, the basic application performance parameters of the membrane, the operation mode and conditions of the equipment, etc., thus optimizing the design of membrane separation equipment with good applicability and high comprehensive application efficiency.