The early detection of diseases and health disorders is crucial for maintaining good health. To achieve this, there is a pressing need to advance imaging techniques and contrast agents. There is an urgent need for advancements in imaging techniques and contrast agents to achieve fast and detailed imaging of tissue microstructures and accurately characterize lesions. Nanoparticle technology offers a promising solution in this regard, thanks to its unique properties. Metal nanohybrids have garnered significant attention due to their exceptional properties compared to larger individual nanoparticles. Metal and metal oxide nanoparticles represent a novel class of hybrid nanomaterials with a wide range of intriguing properties, finding applications in both nanoscience and biomedical research. Understanding how nanoparticles interact with animal and plant cells is crucial for establishing their significant role and enhancing their effectiveness in health and medical applications. This chapter explores the role of different types of metal-supported nanomaterials and their complex hybrid structures in various biomedical imaging modalities, including antibacterial, antifungal, anticancer applications, and more. Metal and metal oxide nanohybrids are discussed in contexts such as gene delivery, theranostics, and catalysis. Due to their versatility, nanohybrids can be employed in tasks like tumor detection, cell tracking, and visualizing specific disease regions. Future research will focus on developing multifunctional nanoplatforms to ensure accurate, safe, effective, and versatile imaging, which will be essential for future applications in healthcare.