Senescence, once considered as permanent cell cycle cessation, has now become a focal point for therapeutic interventions. Researchers are exploring ways to target senescent cells and improve health span. By eliminating these cells, we may delay age-related diseases and pave the way for healthier aging. One approach involves senomorphics, which are compounds designed to modulate the SASP (Senescence-Associated Secretory Phenotype). The SASP is a mix of signaling molecules that senescent cells release, affecting neighboring cells and the tissue microenvironment. By controlling the SASP, researchers aim to mitigate its pro-inflammatory effects and promote tissue regeneration. Clinical trials are underway to test various senolytic drugs—substances that remove senescent cells in a targeted manner. If successful, senolytics could revolutionize aging-related therapies, allowing us to age gracefully and maintain better health throughout life. This chapter introduces cellular senescence, its relevance in therapy, and the agents that target senescence, including senolytics, senomorphics, and SASP inhibitors. Finally, rejuvenation strategies to reverse cellular senescence are discussed and grouped into extrinsic and intrinsic methods on the basis of the level of intervention.