Dry air is an essential requirement in the fields of food processing, storage, and air conditioning. The high humidity in the air increases the cost of air conditioning systems. Furthermore, traditional air dryers suffer from their low efficiency and high operating costs. The desiccant wheel is an excellent system for continuously generating dry air, which can adsorb moisture and regenerate the desiccant material in one complete rotation. As the design parameters of desiccant wheel are fixed, the performance of the desiccant wheel relies on the operating parameters. This investigation has been conducted to find the optimum rotational speed of the desiccant wheel against a mass flow rate of 160 kg/h. An evacuated tube collector for regeneration is integrated with the desiccant wheel, capable of producing hot air up to 100 °C. The analysis shows that up to 60% dehumidification of air is achieved by the desiccant wheel at 15 RPH. At this speed, the system also achieved a maximum optimization factor of 0.105 and a significantly higher DCOP of 0.38. The system is also able to keep the dry air temperature below 60 °C.