Graphillion is a Python software library that provides functions for solving combinatorial problems related to undirected graphs. Graphillion is easy to install, allowing users to immediately take advantage of its capabilities without knowledge of the data structures used in the library. For a given graph, the library holds all subgraphs of the graph that satisfy specified constraints such as paths, trees, and matchings, as well as all vertex sets on the graph such as independent sets and dominating sets. In addition, it can perform solution enumeration, set operations, and uniform random sampling of solutions. This chapter demonstrates how to use Graphillion with examples of Python code and evaluates its performance.