The healthcare system is rapidly evolving from a one-size-fits-all approach to personalized medicine and digital twins, driven by advancements in smart technologies such as artificial intelligence (AI), machine learning (ML), and deep learning (DL). These technologies are propelling the healthcare industry to new heights. The United Arab Emirates (UAE) is widely recognized as a leader in the digital transformation of healthcare, with AI playing a crucial role in diversifying the economy and driving progress through technology. This chapter provides a comprehensive overview of the impact of AI on healthcare, including its historical role in transforming the sector. It explores the successful implementation of AI in the UAE’s healthcare sector while also discussing future perspectives and the positive influence it has on strengthening the global economy.